Quattroflow Quaternary Diaphragm Pumps Applications

How Quattroflow™ Quaternary Diaphragm Pumps Work

Quattroflow™ Quaternary Diaphragm Pumps are truly unique in that their method of operation mimics that of the human heart, which is the perfect model for the safe, reliable and efficient transfer of biological materials. The low-friction, low-shear and low-pulsation operation of Quattroflow pumps with minimal corresponding temperature increase makes them ideal for critical applications within biopharmaceutical manufacturing, including Tangential Flow Filtration (TFF), Chromatography (RFC), centrifuge feed, sterile virus filtration, purification and inline dilution. Quattroflow pumps can also be outfitted with a single-use liquid chamber, which enables them to meet strict speed-to-market manufacturing demands.

Markets Served

Biopharmaceutical

Quattroflow™ develops and manufactures single-use and multiple-use Quaternary (Four-Piston) Diaphragm Pumps for critical applications in the biopharmaceutical industry. This technology is CIP/SIP capable and offers disposable solutions that increase flexibility, reduce down-time, eliminate costs of cleaning validation, and risks of cross-contamination.

Quattroflow pumps can be found in all areas of biologic manufacturing such as cross-flow filtration systems, chromatography, and centrifuges. Quattroflow ensures safety, efficiency and reliability for handling biologics such as plasma products, therapeutic proteins, monoclonal antibodies, vaccines, and other high value

Typical Applications and Products Handled:

  • Chromatography systems
  • Cross-flow systems, TFF
  • Centrifuges
  • Homogenizers
  • Direct flow filters
  • Reaction dosing
  • Virus or sterile filtration
  • Depth filtration
  • Buffer mixing systems
  • Blood plasma fractionation
  • Virus cultures
  • Bacterial and viral vaccines
  • Cell cultures
  • Cell cultures supernatants
  • Enzyme solutions
  • Antibodies
  • Virus inactivation

The Costly Implications of Non-Optimized Transfer

Reducing the amount of wasted product is the obvious primary goal of product recovery. Using pump technologies that are unable to strip lines can have a “snowball effect” on the manufacturing operation’s total cost of doing business. For example, inadequate line-stripping and inefficient product-recovery require:

  • More water to clean the lines
  • Additional cleaning chemicals to clean the lines
  • Sanitizing chemicals to sanitize the lines
  • Energy to facilitate the cleaning process
  • Labor costs to perform longer cleaning operations
  • Disposal costs of used water and chemicals
  • Disposal of product that is no longer usable
  • Water treatment costs and associated treatment chemicals
  • More time for cleaning, which means less time for actual production

Quattroflow Pumps in the Up- and Downstream Processing of Monoclonal Antibodies

Single-Use Pumps

The Single-Use Advantage

Quattroflow single-use pumps have a disposable product wetted chamber constructed of solid polypropylene (PP) or injection-molded polyethylene (PE) that can be replaced as a complete unit. The simple disposability of the pump chamber saves time and money by eliminating cleaning validation, sterilization and product cross-contamination. Single-use pumps are critical to reduce equipment turnaround times in the development biosimilar processes. In general, multi-product facilities are the typical field of application of the single use pumps (e.g. process development, production of clinical reference samples, contract manufacturing).

Multiple-Use Pumps

Pump Development for Special Applications Biopharmaceutical processes require the highest level of purity, containment and cleanability. Quattroflow pumps meet these requirements as they are specially designed for such applications. Quattroflow provides the most versatile and efficient stainless-steel multiple-use pumps for worldwide applications in laboratories, pilot plants and production plants.

  • Chromatography systems
  • Cross-flow systems, TFF
  • Centrifuges
  • Homogenizers
  • Direct flow filters
  • Reaction dosing
  • Virus or sterile filtration
  • Depth filtration
  • Buffer mixing systems
  • Blood plasma fractionation
  • Virus cultures
  • Bacterial and viral vaccines
  • Cell cultures
  • Cell cultures supernatants
  • Enzyme solutions
  • Antibodies
  • Virus inactivation
  • DF/MF/UF filters
  • Minimal maintenance
  • Minimal downtime
  • Low pulsation
  • Superior containment
  • Variable wide flow
  • Capable of dry run
  • Self-priming
  • Cleanable outer surface
  • Linear turndown
  • Compact design
  • Low heat input
  • High purity
  • Minimum particle shedding
  • Quiet operation
  • Lower life cycle cost
  • Ease of use
  • Quick start-up
  • Scaleable
  • No cell damage
  • Low shear
  • Stainless steel materials of construction
  • Single-use pump chamber: Solid polypropylene or injection-molded polyethylene
  • Valves: EPDM
  • Diaphragm: TPE (EPDM/PP)
  • Flow range: 1 lph – 20,000 lph (0.017 – 333 lpm)
  • Max. discharge pressure: 6 bar (87 psi)
  • Max. temperature: 130°C (266°F)